Welcome to the webpage of the Althaus laboratory.
Our group is based in the School of Natural and Environmental Sciences at Newcastle University, Newcastle upon Tyne, U.K.
We investigate the molecular regulation of ion channels and transporters as well as the mechanisms of electrolyte and water transport processes across epithelial tissues.
RECENT RESEARCH NEWS
Transporters and symbiosis
We were part of a study which was the first to identify and characterise an amino acid transporter required for amino acid exchange between the pea aphid (Acyrthosiphon pisum) and its intracellular symbiont Buchnera aphidicola. The study was recently published in the Proceedings of the National Academy of Sciences of the USA.
Epithelial and Membrane Transport Symposium 2018
The Epithelia and Membrane Transport Satellite Symposium in advance of Europhysiology 2018 was a great success. Read more about our exciting speakers and programme!
Activation of CFTR by hydrogen sulfide
We dissected a mechanism by which the gas hydrogen sulfide interferes with cAMP signalling and stimulates the chloride channel CFTR in vitro.
A pH-sensitive ion channel
We recently discovered that an isoform of the epithelial sodium channel (ENaC) in Xenopus laevis is highly sensitive to extracellular protons. This study has implications for molecular ENaC physiology and gives insight into ENaC evolution in vertebrates.
Bird lung physiology
Our Stage 3 project student Mollie Morgan-Jones created nice stop motion animations explaining the respiratory system in birds. Watch here:
O2-sensing in airway epithelia
Reef corals and airways?
What do reef corals and airway epithelia have in common? Find out in an exciting multi-disciplinary review article published in npj Biofilms and Microbiomes.
A protease-resistant ENaC
We discovered that subunit composition critically determines protease sensitivity of the epithelial sodium channel (ENaC) in Xenopus laevis.
Together with Professor Kenneth Olson (Notre Dame University, USA) we revealed a novel mechanism for hypoxic inhibition of electrolyte transport in airway epithelia.